Winter Quarter Our paper, “Multipath Natural Product Suplement Supresses Dementia Symptoms in Amyloid-B and Tau Transgenic Drosophila” is published in The Journal of Biology and Medical Research in January. Work continues on a paper detailing our human pilot study results, “Botanical Mixture Stabilizes Cognitive Function in Patients with Mild and Moderate Alzheimer’s Disease.” Spring Quarter […]
August 17, 2018 Abstract Context: Currently, there is no treatment that can stop the progression of Alzheimer’s disease. We have used transgenic Drosophila melanogaster models and machine learning to develop an eight component botanical mixture (Geneaire™ ReBuilder™) that targets multiple genetic pathways involved in brain aging and dementia that are homologous between Drosophila and humans. […]
January 18, 2018 Abstract Background: Numerous reports on Alzheimer’s Disease (AD) indicate that AD has many biochemical pathways. However, most AD treatments have targeted a single pathway such as beta amyloid or phosphorylated tau and have not been very successful in stopping AD progression. To address the multipath nature of AD, we have used multiple […]
Winter Quarter Work continues on a paper that describes our transgenic Alzheimer’s fly model and the human pilot study we conducted as a result of studies using that model. Some preliminary data analysis of the MX100a patient registry, which has grown to over 150 individuals, shows that the human pilot results are in fact being […]
Winter Quarter Our Gen31 experiment assays the transgenic Tau Alzheimer’s Disease (AD) flies and our “B” flies with MX100a, memantine (Namenda), and combinations of the two therapies. Memantine (Namenda), is one of only a few “first line” therapies used to treat AD. Genescient made the decision to test memantine using our fly model to validate […]
December 22, 2016 Abstract Experimental evolutionary genomics now allows biologists to test fundamental theories concerning the genetic basis of adaptation. We have conducted one of the longest laboratory evolution experiments with any sexually-reproducing metazoan, Drosophila melanogaster. We used next-generation resequencing data from this experiment to examine genome-wide patterns of genetic variation over an evolutionary time-scale […]
April 16, 2015 Abstract Genetic studies indicate that aging is modulated by a great number of genetic pathways. We have used Drosophila longevity and stress assays to test a multipath intervention strategy. To carry out this strategy, we supplemented the flies with herbal extracts (SC100) that are predicted to modulate the expression of many genes […]
Genescient’s Methuselah flies are more vigorous. “They beat up the other flies and take their women away,” said Gregory Benford, a retired UC Irvine physics professor.
Winter Quarter Dr. Robin Mockett, at University of Alabama, confirmed the longevity benefits of MX-100 on his fruit flies under certain conditions. We begin writing the MX-100 paper, reporting these longevity results, with the goal of submitting to Plos One. The Genescient Lab begins planning transgenic fly experiments with the 9 genes that we think […]
Winter Quarter We collected the remaining O flies (“RO”) from the Rose lab at UCI, and Genescient now houses ALL O flies. In our Gen9 experiment, we tested MX-100 again. This time, we included a cohort of flies that didn’t get the treatment until mid-life. The reasoning behind this was to simulate what it might […]